Powered By
Foundayo (orforglipron) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with obesity or adults with overweight who have at least one weight-related health condition. It should be used with a reduced-calorie diet and increased physical activity to help reduce excess body weight and maintain long-term weight loss.
Foundayo is a type of medication called a glucagon-like peptide 1 (GLP-1) receptor agonist, but the exact way it works for weight loss is not fully known. It changes signals in the body that help control appetite and food intake. In obesity, this may help reduce excess body weight and support long-term weight loss.
Doctors prescribe Foundayo with a reduced-calorie diet and more physical activity for adults with obesity, or for adults with overweight who also have at least one weight-related health condition.
Foundayo is given as a tablet by mouth once daily. It can be taken with or without food. The tablet should be swallowed whole. Do not break, crush, or chew the tablet.
The recommended starting dose of Foundayo for obesity in adults is 0.8 milligrams once daily. After at least 30 days, the dose is increased to 2.5 milligrams once daily. After at least 30 days on the 2.5-milligram dose, the dose is increased to 5.5 milligrams once daily.
Based on treatment response and tolerability, doctors may continue increasing the dose step by step after at least 30 days on the current dose. Additional dose levels include 9 milligrams, 14.5 milligrams, and 17.2 milligrams once daily. The maximum dose is 17.2 milligrams once daily.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
In clinical trials of Foundayo in adults with obesity or overweight, the most common side effects occurred in 5 percent to 35 percent of people. These include:
Foundayo can cause serious side effects that require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Eli Lilly and Company, the manufacturer of Foundayo, offers the Foundayo Savings Card Program. Eligible people with commercial insurance may pay as little as $25 per month for Foundayo.
The Foundayo Savings Card Program also offers a post-transaction reimbursement option through an online patient reimbursement portal for eligible people whose savings could not be applied at the pharmacy. To learn more, visit the Foundayo Savings Card Program or call 800-545-5979.
Before taking Foundayo, tell your doctor if you have or have had problems with your pancreas, kidneys, stomach, digestion, or eyes related to diabetes, including diabetic retinopathy. Also tell your doctor if you are planning to have surgery or a procedure that uses general anesthesia or deep sedation.
Tell your doctor if you have any allergies to orforglipron or any ingredients in Foundayo. Do not take Foundayo if you have had a serious allergic reaction to orforglipron or any ingredients in Foundayo.
Do not take Foundayo if you or anyone in your family has ever had medullary thyroid carcinoma (MTC), or if you have multiple endocrine neoplasia syndrome type 2 (MEN 2).
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.
Tell your doctor if you take insulin or diabetes medicines that increase insulin release, such as sulfonylureas, because these medicines may increase the risk of low blood sugar when used with Foundayo.
If you miss a dose, take it as soon as possible. Do not take two doses at the same time or double your next dose. If you miss seven or more doses in a row, restart dose escalation at a lower dose to reduce the risk of stomach-related side effects.
If you use oral hormonal birth control, switch to a non-oral birth control method or add a barrier method for 30 days after starting Foundayo and for 30 days after each dose increase.
There is a pregnancy exposure registry for women exposed to Foundayo during pregnancy. Pregnant people and healthcare providers can contact Eli Lilly and Company at 800-545-5979 for more information.
If you are pregnant or planning to become pregnant, tell your doctor before taking Foundayo. Foundayo may harm your baby if you are pregnant. Stop taking Foundayo if you become pregnant.
Breastfeeding is not recommended during treatment with Foundayo.
These answers are fact-checked by our editorial staff.
How effective is Foundayo?
In studies lasting 72 weeks, adults with obesity or overweight and at least one weight-related health condition lost more weight with Foundayo plus a reduced-calorie diet and increased physical activity than with placebo (an inactive treatment) plus lifestyle changes.
In adults without type 2 diabetes, average body weight change was:
People taking placebo had an average weight change of minus 2.1 percent.
In adults with type 2 diabetes, average body weight change was:
People taking placebo had an average weight change of minus 2.5 percent.
What tests or monitoring are needed with Foundayo for obesity?
Routine monitoring with serum calcitonin testing or thyroid ultrasound is of uncertain value for early detection of medullary thyroid carcinoma (MTC).
If you have type 2 diabetes, your blood glucose should be checked before starting Foundayo and during treatment.
Kidney function should be monitored if you have side effects that could lead to dehydration or volume depletion, such as nausea, vomiting, or diarrhea.
People with a history of diabetic retinopathy should be monitored for worsening diabetic retinopathy or vision changes during treatment.
What should I do if I miss a dose of Foundayo for obesity?
If you miss a dose, take it as soon as possible. Do not take two doses at the same time or double your next dose.
If you miss seven or more doses in a row, restart dose escalation at a lower dose to reduce the risk of stomach-related side effects.
On MyObesityTeam, people share their experiences with obesity, get advice, and find support from others who understand.
Become a member to get even more
Join
Your Privacy Choices
